Ddb1- and cul4-associated factor 8
WebNov 2, 2024 · Furthermore, we revealed that DDB1- and CUL4-associated factor 1 (DCAF1) was downregulated in aged Tregs and was critical to restrain Treg aging via reactive oxygen species (ROS) regulated by glutathione-S-transferase P (GSTP1). Importantly, interfering with GSTP1 and ROS pathways reinvigorated the proliferation … WebPMID: 33857330. DOI: 10.1002/bies.202400057. Abstract. Deciphering how DCAFs (DDB1-CUL4 Associated Factors) modulate a broad spectrum of cellular processes, including …
Ddb1- and cul4-associated factor 8
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WebSep 26, 2024 · Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human DCAF8L1 (DDB1 and CUL4 associated … WebAug 20, 2024 · Here, we show that DDB1 and CUL4 associated factor 8 (DCAF8), which can form a functional E3 ligase complex (CRL4DCAF8), has a strong interaction with the MLF2 protein. DCAF8 could promote MLF2 degradation through the …
WebNational Center for Biotechnology Information WebThe cullin 4 (CUL4)-damage-specific DNA binding protein 1 (DDB1)-cereblon (CRBN) E3 ubiquitin ligase co-exists in the same complex with and promotes the degradation of ClC …
WebDDB1 is also a component of an ubiquitin-E3 ligase complex and functions as substrate or adapter protein between Cullin 4A (Cul4A) and CUL4-associated factors (DCAFs) to target substrates for ubiquitination. CUL4-DDB1 E3-ligase complex regulates the selective proteolysis of key proteins in DNA repair, replication and transcription. WebAug 2, 2016 · DDB1 and CUL4 associated factor 11 (DCAF11) mediates degradation of Stem-loop binding protein at the end of S phase ... (SLBP), which binds to 3' ends of …
WebJun 15, 2024 · DDB1- and CUL4-associated factor 8 plays a critical role in spermatogenesis Xiuli Zhang; Zhizhou Xia; Ruibao Ren; Frontiers of Medicine (2024)
WebJun 22, 2007 · The CUL4-DDB1 ubiquitin ligase regulates cell proliferation, survival, DNA repair, and genomic integrity through targeted ubiquitination of key regulators, yet the substrate receptors that dictate the specificity of this ubiquitination machinery have been largely unknown. musubu リストWebThe DDB1 is acetylated and acetylation promotes DDB1 binding to CUL4. Results revealed a function independent of its transcriptional activity, as TTF-1 was found to interact with DDB1 and block its binding to CHK1, which in turn attenuated ubiquitylation and subsequent degradation of CHK1. SIRT7 inhibits TR4 degradation by deacetylation of DDB1. muta 8バッグWebDec 8, 2024 · Gene ID: 320808, updated on 8-Dec-2024 Summary Located in mitochondrion. Orthologous to human DCAF5 (DDB1 and CUL4 associated factor 5). [provided by Alliance of Genome Resources, Apr 2024] Other designations DDB1- and CUL4-associated factor 5, WD repeat domain 22, WD repeat-containing protein 22 muta marine tokyo ムータ・マリン トーキョーWebDDB1- AND CUL4-ASSOCIATED FACTOR 8; DCAF8 Alternative titles; symbols WD REPEAT-CONTAINING PROTEIN 42A; WDR42A HGNC Approved Gene Symbol: DCAF8 Cytogenetic location: 1q23.2 Genomic coordinates (GRCh38): 1:160,215,720-160,262,549 (from NCBI) Gene-Phenotype Relationships PheneGene Graphics TEXT Description mutant vsti インストールWebconditions.DDB1-andCUL4-associatedfactor8 (DCAF8)isaWD40repeat-containingprotein,whichservesasa substrate receptor for CRL4. The physiological role of … mus工法とはWebDec 21, 2004 · DDB1- and CUL4-associated factor 8 Alternative names WD repeat-containing protein 42A Gene names Name DCAF8 Synonyms H326, WDR42A Organism … muta x bonfanti クラッチバッグ・ネオプレーンWebDDB1- AND CUL4-ASSOCIATED FACTOR 13; DCAF13 Alternative titles; symbols WD REPEAT- AND SOF1 DOMAIN-CONTAINING PROTEIN 1; WDSOF1 HGNC Approved Gene Symbol: DCAF13 Cytogenetic location: 8q22.3 Genomic coordinates (GRCh38): 8:103,415,386-103,443,453 (from NCBI) TEXT Description muta marine ムータマリン ボンディングパンツ キルティング切替